MT1

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MT-1 (Melanotan-1 / Afamelanotide) is a synthetic linear analogue of alpha-melanocyte stimulating hormone (α-MSH), differing from the native peptide by a single amino acid substitution (norleucine for methionine at position 4) which confers enhanced receptor binding affinity and metabolic stability. It acts as a potent MC1R agonist and is studied for its roles in melanogenesis, UV-response pathways, and photoprotection biology.

MT-1 has been the subject of both preclinical and clinical research. The EMA-approved form (afamelanotide) is used clinically for erythropoietic protoporphyria — making this one of the few melanocortin research peptides with a regulatory approval precedent. Preclinical research explores MC1R-mediated signalling, pigmentation pathways, immune modulation, and inflammatory response.

CAS: 75921-69-6  ·  Formula: C78H111N21O19  ·  MW: 1646.9 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: MC1R pharmacology · Melanogenesis · UV photoprotection · Erythropoietic protoporphyria models · Immune modulation · Anti-inflammatory signalling

Research Literature:
• PubMed: Melanotan-1 / Afamelanotide research literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.