MT2

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MT-2 (Melanotan II) is a synthetic cyclic lactam analogue of alpha-MSH, engineered for enhanced receptor binding affinity and metabolic stability versus the linear native peptide. It is a broadly promiscuous melanocortin receptor agonist, acting on MC1R, MC3R, MC4R, and MC5R — covering skin pigmentation, energy homeostasis, sexual function signalling, and exocrine gland biology respectively.

MT-2 is one of the most studied melanocortin peptides in receptor pharmacology research. Its relative selectivity profiles across MCR subtypes, its cyclic lactam structure-activity relationships, and its downstream signalling via cAMP/PKA pathways make it a versatile research tool for melanocortin system biology. It remains widely used in preclinical CNS, metabolic, and dermatological research.

CAS: 121062-08-6  ·  Formula: C50H69N15O9  ·  MW: 1024.2 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: MC1R / MC3R / MC4R / MC5R pharmacology · Melanogenesis · Energy homeostasis · Melanocortin CNS pathways · Structure-activity relationship (SAR) studies · cAMP / PKA signalling

Research Literature:
• PubMed: Melanotan II research literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.