5-Amino 1MQ

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5-Amino-1MQ (5-amino-1-methylquinolinium iodide; CAS 42464-96-0) is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that methylates nicotinamide (vitamin B3) to produce 1-methylnicotinamide, thereby consuming SAM (S-adenosylmethionine) and depleting methyl group availability for epigenetic and metabolic processes. NNMT is highly expressed in adipose tissue, where its activity correlates with obesity, insulin resistance, and metabolic syndrome.

By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD⁺ precursor availability, restores methyl group balance, and has been shown in preclinical models to reduce adiposity and improve insulin sensitivity. It is studied as a research tool for NNMT biology, one-carbon metabolism, NAD⁺/NADH homeostasis, and epigenetic methylation dynamics in metabolic disease models.

CAS: 42464-96-0  ·  Formula: C10H11IN2 (iodide salt)  ·  MW: 286.1 g/mol  ·  Purity: ≥98% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C, protected from light

Research Areas: NNMT inhibition · NAD⁺ metabolism · One-carbon metabolism · Epigenetic methylation · Adipogenesis · Metabolic disease models · SAM/SAH ratio

Research Literature:
• PubMed: 5-Amino-1MQ research literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.