Adipotide

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Adipotide (CKGGRAKDC-GG-D(KLAKLAK)₂) is a chimeric pro-apoptotic peptide comprising two functional domains: a vascular-targeting domain (CKGGRAKDC) that binds to prohibitin-1 and annexin A2 on the surface of blood vessels feeding adipose tissue, and a cell-disrupting domain (D(KLAKLAK)₂) that induces mitochondrial apoptosis upon internalisation.

Originally developed for cancer vasculature targeting, Adipotide was repurposed as an adipose-selective pro-apoptotic agent. Preclinical studies in obese non-human primates demonstrated significant reduction in body mass and waist circumference through targeted elimination of fat-feeding vasculature, establishing it as a key research tool in adipose biology, angiogenesis targeting, and metabolic disease research.

PubChem CID: 163360068  ·  Formula: C111H206N36O28S2  ·  MW: ~2,700 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: Adipose vascular targeting · Prohibitin / annexin A2 biology · Pro-apoptotic peptide design · Obesity & metabolic disease models · Angiogenesis research · Chimeric peptide pharmacology

Research Literature:
• PubMed: Adipotide research literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.