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Peptide Biosciences

GHK-CU

GHK-CU

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GHK-Cu (Copper Tripeptide-1) (Gly-His-Lys·Cu²⁺; CAS 49557-75-7) is a naturally occurring copper peptide complex found in human plasma, saliva, and urine. Serum concentrations decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60, making it a subject of significant interest in aging biology. GHK-Cu is extensively studied for its role in extracellular matrix remodelling, collagen and glycosaminoglycan synthesis, wound healing, and skin regeneration.

Research has demonstrated that GHK-Cu activates a broad programme of skin remodelling genes, stimulates both synthesis and regulated breakdown of collagen via metalloproteinase modulation, and promotes wound healing across multiple tissue types including skin, hair follicles, gastrointestinal tract, and bone. Its antioxidant and anti-inflammatory properties have been documented in numerous in vitro and in vivo studies.

CAS: 49557-75-7  ·  Formula: C14H24CuN6O4  ·  MW: 403.9 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: Collagen synthesis & ECM remodelling · Wound healing · Skin regeneration · Anti-inflammatory signalling · Hair follicle biology · Angiogenesis · Anti-aging research

Selected Research Literature:
GHK as an anti-aging peptide: mechanisms and potential (PMID 35083444)
GHK as modulator of multiple cellular pathways in skin regeneration (PMID 26236730)
Stem cell recovering effect of copper-free GHK in skin (PMID 23019153)
Full PubMed literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.

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