KPV
KPV
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- For in vitro laboratory research use only
Concentration calculator
For laboratory calculation only. Not for human or veterinary use.
KPV (Lys-Pro-Val; α-MSH residues 11–13) is the C-terminal tripeptide of alpha-melanocyte stimulating hormone (α-MSH). While short, KPV retains the principal MC1R-binding activity of the parent 13-residue peptide, acting primarily via MC1R-mediated pathways to suppress NF-κB activation and pro-inflammatory cytokine release (TNF-α, IL-1β, IL-6) in immune and epithelial cell models.
KPV has been studied in preclinical models of intestinal and skin inflammatory signalling. Its small molecular size, resistance to proteolysis (conferred by the C-terminal valine), and ability to modulate both innate immune and adaptive inflammatory responses make it a highly versatile research peptide. It has been explored for delivery via oral and topical routes in preclinical models.
Research areas
- MC1R-mediated signalling
- NF-κB pathway
- Cytokine signalling
- Intestinal epithelial models
- Skin inflammation models
Selected literature
Sequence: H-Lys-Pro-Val-OH (α-MSH 11–13) · MW: 341.4 g/mol · Purity: ≥99% HPLC · Format: Lyophilised powder · Storage: −20 °C.
Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.
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