MOTS-C
MOTS-C
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- Independent test: Janoshik Analytical, June 2026 · View report
- For in vitro laboratory research use only
Concentration calculator
For laboratory calculation only. Not for human or veterinary use.
MOTS-c (Mitochondrial Open Reading Frame of 12S rRNA-c) is a 16-amino-acid mitochondria-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial 12S rRNA gene. Discovered by Lee et al. in 2015, it represents a novel class of mitochondria-encoded hormones. MOTS-c is studied for its role in metabolic homeostasis, AMPK activation, insulin sensitivity, and adaptation to cellular stress.
Research has established MOTS-c as primarily acting on skeletal muscle, where it inhibits the folate cycle and de novo purine biosynthesis, leading to AMPK activation and improved metabolic signalling. Murine studies have examined its effects on insulin signalling and diet-induced metabolic changes, making it a research target in metabolic, ageing and exercise biology.
Research areas
- Metabolic homeostasis
- AMPK activation
- Insulin signalling
- Metabolic disease models
- Mitochondrial biology
- Exercise physiology
- Aging research
Selected literature
PubChem CID: 176489569 · Formula: C101H152N28O22S2 · MW: ~2,147 g/mol · Purity: ≥99% HPLC · Format: Lyophilised powder · Storage: −20 °C.
Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.
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