MOTS-C

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MOTS-c (Mitochondrial Open Reading Frame of 12S rRNA-c) is a 16-amino-acid mitochondria-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial 12S rRNA gene. Discovered by Lee et al. in 2015, it represents a novel class of mitochondria-encoded hormones. MOTS-c is studied for its role in metabolic homeostasis, AMPK activation, insulin sensitivity, and adaptation to cellular stress.

Research has established MOTS-c as primarily acting on skeletal muscle, where it inhibits the folate cycle and de novo purine biosynthesis, leading to AMPK activation and improved metabolic signalling. In murine studies, MOTS-c treatment prevented age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity, positioning it as a key research target in metabolic disease, aging, and exercise biology.

PubChem CID: 176489569  ·  Formula: C101H152N28O22S2  ·  MW: ~2,147 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: Metabolic homeostasis · AMPK activation · Insulin sensitivity · Obesity models · Mitochondrial biology · Exercise physiology · Aging research

Selected Research Literature:
• MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (PMID 25738459)
• MOTS-c: a novel MDP regulating muscle and fat metabolism (PMID 27216708)
• Full PubMed literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.