NAD+

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NAD⁺ (Nicotinamide Adenine Dinucleotide) (CAS 53-84-9) is a fundamental coenzyme present in all living cells, functioning as an electron carrier in redox reactions and as a substrate for a broad class of enzymes including sirtuins (SIRT1–7), PARPs (poly ADP-ribose polymerases), and CD38. NAD⁺ levels decline with age and in conditions of metabolic stress, linking it to aging biology, DNA repair capacity, mitochondrial function, and circadian rhythm regulation.

In research settings, NAD⁺ is studied as a substrate for sirtuin-mediated deacetylation reactions, a regulator of PARP-1-dependent DNA damage responses, and a mediator of calcium signalling via CD38/cADPR pathways. Supplementation studies have investigated its role in restoring mitochondrial function, improving insulin sensitivity, and modulating the aging transcriptome in model organisms.

CAS: 53-84-9  ·  Formula: C21H27N7O14P2  ·  MW: 663.4 g/mol  ·  Purity: ≥98%  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: Sirtuin substrate biology · PARP-1 / DNA repair · Mitochondrial bioenergetics · Aging & longevity research · Metabolic regulation · Circadian rhythm · CD38 signalling

Research Literature:
• PubMed: NAD⁺ research literature →

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