Snap-8

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Snap-8 (Acetyl Octapeptide-3) is a synthetic eight-amino-acid acetylated peptide studied for its ability to inhibit SNARE complex formation at the neuromuscular junction. It mimics the N-terminal domain of SNAP-25, one of the three SNARE proteins required for synaptic vesicle fusion, thereby competitively reducing acetylcholine release and attenuating muscle contraction in research models.

As a longer-chain analogue of acetyl hexapeptide-3 (Argireline), Snap-8 is studied for its improved potency in SNARE inhibition assays and its application in cosmetic and dermatological research focused on dynamic expression line mechanisms. It is a standard reference compound in research on neuromuscular junction pharmacology, SNARE complex biology, and topical peptide delivery.

CAS: 868844-74-0  ·  MW: ~1075 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: SNARE complex inhibition · Acetylcholine release modulation · Neuromuscular junction pharmacology · Cosmetic peptide research · SNAP-25 peptide biology · Topical delivery models

Research Literature:
• PubMed: Snap-8 research literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.