SS-31

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SS-31 (Elamipretide) (D-Arg-2'6'-dimethylTyr-Lys-Phe-NH₂) is a mitochondria-targeting synthetic tetrapeptide with a unique alternating cationic-aromatic sequence that enables rapid, energy-independent accumulation at the inner mitochondrial membrane. It is studied for its role in cardiolipin stabilisation, reactive oxygen species (ROS) reduction, and restoration of mitochondrial cristae architecture.

Preclinical and early clinical research has investigated SS-31 across multiple models of mitochondrial dysfunction, including cardiac ischaemia-reperfusion injury, age-related mitochondrial decline, acute kidney injury, and neurodegenerative disease models. Its mechanism centres on cardiolipin interaction, which restores electron transport chain efficiency and reduces oxidative stress without altering mitochondrial membrane potential.

CAS: 736992-21-5  ·  Sequence: D-Arg-dmTyr-Lys-Phe-NH₂  ·  MW: ~639.8 g/mol  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: Cardiolipin stabilisation · Mitochondrial bioenergetics · ROS reduction · Cardiac ischaemia models · Renal protection · Age-related mitochondrial decline

Research Literature:
• SS-31 ameliorates isoflurane-induced mitochondrial impairment (PMID 28487636)
• PubMed: SS-31 / Elamipretide research literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.