TB-500 (889)

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TB-500 (889) is a synthetic version of the actin-sequestering active region of Thymosin β4, corresponding to the LKKTETQ heptapeptide motif (amino acids 17–23 of full-length Thymosin β4; parent protein CAS 107761-42-2). The 889 designation refers to the specific fragment studied extensively for its role in cellular migration, angiogenesis, and tissue-response pathways.

Research has established that the LKKTETQ actin-binding domain is primarily responsible for the wound-healing and angiogenic activity observed with full-length Thymosin β4. TB-500 sequesters G-actin, reducing the intracellular G/F-actin ratio and thereby promoting cell motility, blood vessel formation, and matrix remodelling. Studies have documented activity in cardiac regeneration, skin wound healing, and musculoskeletal repair models.

Parent Compound CAS: 107761-42-2 (Thymosin β4)  ·  Active Fragment: Ac-LKKTETQ-OH  ·  Purity: ≥99% HPLC  ·  Format: Lyophilised powder  ·  Storage: −20 °C

Research Areas: Actin sequestration · Cellular migration · Wound healing · Angiogenesis · Cardiac repair models · Connective tissue repair

Selected Research Literature:
• Thymosin beta4 accelerates wound healing (PMID 10469335)
• Actin binding site of thymosin beta4 promotes angiogenesis (PMID 14500546)
• TB-500 metabolites and wound healing activity in vitro (PMID 38382158)
• Full PubMed literature →

Research Use Only. Supplied strictly for in vitro laboratory research by qualified professionals. Not for human or veterinary administration. Not evaluated by the MHRA or FDA for therapeutic use. Researchers must comply with the Human Medicines Regulations 2012 and all applicable institutional guidelines. Peptide Biosciences accepts no liability for use outside a controlled research context.